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Antidepressant treatment tachyphylaxis (ADT tachyphylaxis), also known as Prozac poop-out, is a medical condition in which progressive or acute tolerance effects are seen following chronic administration of a drug.〔Bunnel, Craig A. Intensive Review of Internal Medicine, Harvard Medical School 2009.〕 ADT tachyphylaxis specifically refers to a sudden decrease in response to selective serotonin reuptake inhibitors (SSRIs), which are the most commonly prescribed antidepressants.〔http://depression.about.com/od/resistance/f/poopout.htm〕〔http://www.mayoclinic.org/diseases-conditions/depression/in-depth/ssris/art-20044825〕 Although less commonly prescribed as antidepressants (having lost popularity following the introduction of SSRIs), monoamine oxidase inhibitors, or MAOIs, have also incurred a "poop-out" effect among depressed patients.〔http://www.mayoclinic.org/diseases-conditions/depression/in-depth/maois/art-20043992〕 ==Characteristics== Patients affected by ADT tachyphylaxis experience a noticeably sudden progressive decrease in response to SSRIs. The reported rates of this condition vary from 9% to 33% of SSRI users, and the majority of those affected are less responsive to subsequent treatments.〔http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008298/〕 In most observational studies, these individuals suffer a recurrence or relapse of depression without changing the previously effective dose. ADT tachyphylaxis incorporates drug sensitivity as a potential causal factor for the decreased response. However, tolerance provides a more accurate explanation. While the exact cause of ADT tachyphylaxis in individual cases is unknown, drug tolerance is a more comprehensive model, as it includes mechanisms of pharmacodynamic tolerance, metabolic tolerance, and others. ===Common examples=== ADT tachyphylaxis specifically occurs in depressed patients using SSRIs and MAOIs. Currently, SSRIs are the preferred treatment for depression among clinicians, as MAOIs require the patient to avoid certain foods and other medications due to the potential for interactions capable of inducing dangerous side effects. Provided is a list of medications known to be subject to Poop-out. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Antidepressant treatment tachyphylaxis」の詳細全文を読む スポンサード リンク
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